Constipación crónica. Conceptos actuales desde la fisiopatología hasta el tratamiento

Chronic constipation is one of the most frequent gastrointestinal pathologies worldwide, and it negatively impacts quality life patients. The objective this narrative review to present innovative relevant information in relation chronic constipation, from its pathophysiology treatment. It recognized that there are at least three subtypes primary functional, associated with irritable bowel related evacuation disorders. considered multiple causes secondary especially drugs entity called opioid-induced specifically detailed. pathophysiological mechanisms functional (they include motor sensory alterations, dysbiosis, structural alterations pelvic floor) frequently overlap. No test provides a complete description defecation; therefore general, combination these generally used assess structure function. Advanced diagnostic studies function colon, rectum, anus recommended patients whom first-line treatment have failed. Regarding treatment, usefulness hygienic-dietary measures, exercise, fiber, laxatives, new (such as prucalopride, lubiprostone, linaclotide, plecanatide), biofeedback therapy, probiotics, other therapies fecal microbiota transplantation surgery.